It is within the scope of practice of an appropriately prepared and competent registered nurse to perform peritoneal dialysis under the direction of an authorized health care practitioner, following clinical practice standards. The procedure may be performed in a home setting or an in-center setting. A prescription or order from an authorized provider is required. This includes preparing and monitoring the dialysis machine, accessing an arteriovenous (AV) fistula or graft or a central venous catheter, initiating or discontinuing hemodialysis, collecting specimens, catheter site care, and performing tubing or adaptor changes. The registered nurse should use the Scope of Practice Decision Tree to determine if these activities are within the nurse’s legal and individual scope of practice.