The nursing law and rules do not prohibit the competent and appropriately trained licensed practical nurse from giving off-label medications under the direction of an authorized provider or under the direction and supervision of the registered nurse. A prescription or order from an authorized provider is required. The facility can be more restrictive. The Nursing Care Quality Assurance Commission recommends the licensed practical nurse use the Scope of Practice Decision Tree to determine if the administration of the off-label medication is within his or her regulatory and individual scope of practice. The Food and Drug Administration Understanding Unapproved Use of Approved Drugs "Off-Label" website provides information about using unapproved off-label drugs. Off-label use should be done with careful insight and understanding of the risks and benefits to the patient considering high-quality evidence supporting efficacy, effectiveness, and safety. The licensed practical nurse is always individually accountable and responsible for the nursing care the licensed practical nurse provides.